spartan’18 version 18.3.1 (Wavefunction inc)
90
Structured Review
Wavefunction inc
spartan’18 version 18.3.1
Spartan’18 Version 18.3.1, supplied by Wavefunction inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/spartan%E2%80%9918+version+18%2E3%2E1/spartan%E2%80%9918+version+18+3+1/pm31765150-265-26-28
Average 90 stars, based on 1 article reviews
Spartan’18 Version 18.3.1, supplied by Wavefunction inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/spartan%E2%80%9918+version+18%2E3%2E1/spartan%E2%80%9918+version+18+3+1/pm31765150-265-26-28
Average 90 stars, based on 1 article reviews
spartan’18 version 18.3.1 - by Bioz Stars,
2026-09
90/100 stars
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other:Article Title: Elucidation of the Active Conformation of Antiproliferative Sulfonamides, 5 N -Arylsulfonyl-1,5-benzodiazepin-2-ones. Article Snippet: The 5N-arylsulfonyl-1,5-benzodiazepin-2-ones with antiproliferative activity were prepared and successfully separated into the (aR,aR)and (aS,aS)-atropisomers with extraordinary stability (ΔG⧧ = ∼130 kJ/mol) by freezing the conformation around the sp−sp axis in an Ar−N(SO2) moiety with a C6-methyl group.. Also, by introducing a C3-methyl group (central chirality) into the 1,5-benzodiazepine nucleus, the stereochemistry at the axis was biased to take solely one diastereomer with a relative stereochemistry of (aR*,aR*,3R*).. The (aS) stereochemistry was crucial for exerting the antiproliferative activity. |